Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, more...


Article type

Original Article


Article page

245-250


Authors Details

Chaitra S R, Roopa P Nayak*, Uttara Krishna


Article Metrics


View Article As

 


Downlaod Files

   






Article statistics

Viewed: 130

PDF Downloaded: 115


Screening of aqueous extract of Myristica fragrans seed for sedative and sleep enhancing property in experimental animals


Original Article

Author Details : Chaitra S R, Roopa P Nayak*, Uttara Krishna

Volume : 7, Issue : 4, Year : 2020

Article Page : 245-250

https://doi.org/10.18231/j.ijpp.2020.041



Suggest article by email


Abstract

Background: Myristica fragrans houtt or nutmeg, a commonly used spice is found to have several medicinal properties.
Aim: The main aim of our study is to evaluate sedative and hypnotic activity of aqueous extract of Myristica fragrans houtt seeds in experimental animals.
Materials and Methods: This is a preclinical study involving male and femaleWistar albino rats and Swiss albino mice. Sedative and hypnotic properties were assessed using hole board test, open field apparatus, rota rod apparatus and thiopental induced sleeping time. Myristica fragrans aqueous extract( MFAE) was the test drug which was given at the dose of 200mg/kg body weight. Diazepam was used as the standard drug. Preliminary phytochemical analysis of MFAE was carried out.
Statistical Analysis: Data was analyzed using one way ANOVA (Analysis of Variance) followed by Tukey Krammer Test. P value < 0> Results: Hole board test and open field test showed decrease in exploratory and locomotor activity and rota rod test showed decrease in time period of fall compared to normal and thiopental induced sleeping time showed that the test drug decreased the onset time of loss of righting reflex and prolonged the regaining time of righting reflex indicating hypnotic activity. Preliminary phytochemical screening showed the presence of alkaloids, glycosides, saponins, flavonoids, tannins and fixed oils.
Conclusion: Based on results we concluded that aqueous extract of Myristica fragrans seeds possess significant sedative hypnotic property.

Keywords: Myristica fragrans, Sedative, Sleep Swiss albino mice, Wistar albino rats.


How to cite : Chaitra S R, Nayak R P , Krishna U , Screening of aqueous extract of Myristica fragrans seed for sedative and sleep enhancing property in experimental animals. Indian J Pharm Pharmacol 2020;7(4):245-250

Copyright © 2020 by author(s) and Indian J Pharm Pharmacol. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)