Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs.

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Review Article


Article page

121-135


Authors Details

Rosme David, Belinda Mangalath Philip, Clint Sunny, Mamatha J, Vanditha S, Deepthi Mary George, Princy Louis Palatty*


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Therapeutic approaches to tackle COVID-19: An overview


Review Article

Author Details : Rosme David, Belinda Mangalath Philip, Clint Sunny, Mamatha J, Vanditha S, Deepthi Mary George, Princy Louis Palatty*

Volume : 8, Issue : 2, Year : 2021

Article Page : 121-135

https://doi.org/10.18231/j.ijpp.2021.020



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Abstract

Background:  A series of an acute atypical respiratory disease occurred during December 2019 in Wuhan, China, that quickly metamorphosed as a pandemic, spreading across the globe, leaving more than 104,911,186 infected and more than 2,278,579 dead, in its wake within a year. This Novel Coronavirus, was also called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and the disease was called Coronavirus Disease 19 (COVID-19). On 30th January 2020, The World Health Organisation (WHO) Director-General, declared the novel coronavirus outbreak, a public health emergency of international concern and flagged off WHO’s highest level of alarm.
Objectives: To elaborate the various drug therapies used in trials and vaccines available for COVID-19
across the globe.
Materials and Methods: We compiled the literature searches under a single heading and scrutinized over
154 articles, for extracting data on the various pharmacotherapeutic approaches available to treat COVID-
19.
Conclusion: Despite wide and varied treatment guidelines being available, the cure or prevention is still
elusive for COVID-19. The categoric efficacy of vaccines must be proved to tackle the fast-mutating coronavirus.
 

Key findings: Current medical management is largely supportive with no targeted therapy available.
Several drugs including lopinavir-ritonavir, remdesivir, antibiotics, hydroxychloroquine, steroids,
anticoagulants, and antidiabetic drugs like metformin have been tried in clinical trials. Vaccines targeting
the three different components of SARS-CoV-2 viruses, in different phases of clinical trials world-wide,
have been made available.

Keywords: COVID-19, n-COV, Covid Vaccine, Remdesivir, SARS-CoV-2, Cytokine storm, Pandemic.


How to cite : David R , Philip B M , Sunny C , Mamatha J, Vanditha S, George D M , Palatty P L , Therapeutic approaches to tackle COVID-19: An overview. Indian J Pharm Pharmacol 2021;8(2):121-135

Copyright © 2021 by author(s) and Indian J Pharm Pharmacol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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