- Visibility 194 Views
- Downloads 122 Downloads
FORMULATION AND EVALUATION OF TOPICAL SOY-PHYTOSOME CREAM
- Author Details:
-
Aniket *
-
A. Kumari
-
P. Kumari
-
S. Saurabh
-
L. Khurana
-
K. S. Rathore
The bioavailability and absorption of water soluble phyto constituents is erratic due to poor solubility of these constituents in gastrointestinal tract. This can be overcome by a novel delivery system known as phytosome technology in which water soluble phyto constituents are allowed to react with phospholipids. For better and improved bioavailability, natural phyto constituents must have a good balance between hydrophilicity (helps in dissolution in gastro-intestinal fluids) and hydrophobicity (helps to cross lipid rich cell membranes). This is achieved through phytosome technology. Phospholipids have a dual solubility and acts as an emulsifier. Phytosome technology acts as a bridge between novel and conventional delivery systems. Many products are available in the market based on this phytosome technology which includes popular herbal extracts such as Ginkgo biloba, Silybum marianum, grape seed, olive oil flavonoids etc.
Keywords: Phytosomes, Liposomes, Phytoconstituents, Bioavailability,Phospholipid complex.
References
- Ajazuddin SS. Application of novel drug delivery system for herbal formulation. Elsevier- Fitoterapia 81 (2010).
- Kareparamban JA. Phytosome: A Novel Revolution in Herbal Drugs. International Journal of Research in Pharmacy and Chemistry 2012; 2(2).
- Suryawanshi JAS. Phytosome: An emerging trend in herbal drug treatmentβ, Journal of Medical Genetics and Genomics 2011; 3(6).
- Mohd AA. Commercially bio available proprietary technologies and their marketed products. Elsevier- Drug Discovery Today 2013. Available online at www.drugdiscoverytoday.com.
- Bombardelli E. Phytosome: New Cosmetic Delivery System. BollChim Farm. 1991; 130:431-38.
- Bombardelli E, Spelta M. Phospholipid-Polyphenol Complexes: A New Concept in Skin Care Ingredients. Cosm. & Toil.1991; 106:69-76. Aniket et al. Formulation and Evaluation of Topical Soy-Phytosome Cream Indian Journal of Pharmacy and Pharmacology, April-June 2015;2(2);105-112 112
- Murray D. Phytosomes- Increase the Absorption of Herbal Extract 2008. (Online available at- www.doctormurray.com/articles/silybin.htm).
- Choubey A. Phytosomes: A Novel Approach for Herbal Drug Delivery. International Journal of Pharmaceutical Sciences and Research 2011; 2(4): 807-816.
- Chowdhury RS. Phytosome: An Emerging Technology in Phytomedicine. International Research Journal of Pharmacy 2012; 3(10): 60-64.
- Jain N. Phytosome: A Novel Drug Delivery System for Herbal Medicine. International Journal of Pharmaceutical Sciences and Drug Research 2010; 2(4): 224-228.
- Vangapelli S. Phytosome: A Novel Drug Delivery System for Improving Bioavailability of Herbal Medicine. International Journal of Pharmaceutical Research and Development 2011; 3(6): 174-184.
- Tripathy S. A review on Phytosomes, Their characterization, advancement and potential for transdermal application. Journal of Drug Delivery and Therapeutics2013; 3(3): 147-152.
- www.drugbank.ca/drugs/DB01645.
- www.soyconnection.com_sites_default_files_Soy- Lecithin-Fact-Sheet.
- Rathore P, Swami G. A potential phyto-phospholipid carrier for the bioavailability enhancement of herbal extracts. International Journal of Pharmaceutical Sciences and Research (IJPSR) 2012; 3: 3.
- http://en.wikipedia.org/wiki/Precipitation.
- http://www.freezedrying.com/freeze_drying_principles4. html.
- Swarbrick BJ. Spray drying and spray congealing of pharmaceuticals encyclopaedia of pharmaceutical technology. Marcel Dekker. 1992, 207-221.
- He P, Davis SS, Illum L. Chitosan microspheres prepared by spray drying. International journal of pharmacy 1999, 53β65.
- Saha S. Phytosome: A Brief Overview. Scholars Academic Journal of Pharmacy (SAJP)2013; 2(1):12-20.
- Agarwal VK. Improvement in Bioavailability of Class- III Drug: Phytolipid Delivery System. International Journal of Pharmacy and Pharmaceutical Sciences 2012; 4 (1): 37-42.
- Babitta R. Phytosomes: A potential carrier for herbal drugs. International Journal of Research and Reviews in Pharmacy and Applied Science (IJRRPAS); 2(3), 566-
- Haijun H. Phytosomes: an effective approach to enhance the oral bioavailability of active constituents extracted from plants. Journal of Chinese Pharmaceutical Sciences 2013; 385-08.
- Khan J. Recent advances and future prospects of phyto- phospholipid complexation technique for improving pharmacokinetic profile of plant actives. Journal of Controlled Release (JCR) 2013; 168: 50-60.
How to Cite This Article
Vancouver
Aniket , Kumari A, Kumari P, Saurabh S, Khurana L, Rathore KS. FORMULATION AND EVALUATION OF TOPICAL SOY-PHYTOSOME CREAM [Internet]. Indian J Pharm Pharmacol. 2015 [cited 2025 Oct 07];2(2):105-112. Available from: https://doi.org/
APA
Aniket, , Kumari, A., Kumari, P., Saurabh, S., Khurana, L., Rathore, K. S. (2015). FORMULATION AND EVALUATION OF TOPICAL SOY-PHYTOSOME CREAM. Indian J Pharm Pharmacol, 2(2), 105-112. https://doi.org/
MLA
Aniket, , Kumari, A., Kumari, P., Saurabh, S., Khurana, L., Rathore, K. S.. "FORMULATION AND EVALUATION OF TOPICAL SOY-PHYTOSOME CREAM." Indian J Pharm Pharmacol, vol. 2, no. 2, 2015, pp. 105-112. https://doi.org/
Chicago
Aniket, , Kumari, A., Kumari, P., Saurabh, S., Khurana, L., Rathore, K. S.. "FORMULATION AND EVALUATION OF TOPICAL SOY-PHYTOSOME CREAM." Indian J Pharm Pharmacol 2, no. 2 (2015): 105-112. https://doi.org/