Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, more...


  • Article highlights
  • Article tables
  • Article images

Article statistics

Viewed: 95

PDF Downloaded: 44


Suthar and Patel: A prospective longitudinal study of medication errors in private hospital of metropolitan city of Gujarat


Introduction

Any preventable event that may cause or lead to inappropriate medication use or patient harm, while the medication is in the control of the health care professional, patient or consumer- medication errors; defined by The National Coordinating Council for Medication Error (NCCMER).1 Medication errors are a common occurrence and continue to be a problem in the health care industry. It depends on successful interaction among health care professionals functioning at different areas. Errors may occur at any stage of prescribing, documenting, dispensing, preparation, or administration.2, 3 It may also a leave a negative impression on the minds of people about the hospital and may directly impact their lives. Approximately, 28% of adverse drug events (ADEs) are related to medication errors Estimation of drug-related morbidity and mortality is nearly $ 177 billion in the US. There is at least one death per day and 1.3 million people are injured each year due to medication errors4, 5 other factors that can contribute are job-related stress, improper training or education and sound-alike lookalike packaging of medications. This issue has also received considerable attention in the lay press.6 Phillips J. et al. did a retrospective analysis of medication errors between 1993 – 1998 and found that the most common types of errors were from administering improper dose (40.9%); overdose (36.4%), wrong drug (19%) and wrong route of administration (9.5%). The investigators also found that the most common causes of errors were performance and knowledge deficits (44%) and communication errors (15.8%).7 As per USP MEDMARX 2002 report, geriatric patients are involved in more than one-third of medication errors. Reasons for the same were found to be in administration phase of the medication use.

Pharmacists played important role in improving medication safety and have studied to reduce medication errors. Research by pharmacists documented the incidence of drug administration errors in hospitals in the United States as being 10 per cent or higher.4 This provided the evidence and impetus to develop drug distribution systems that were safer, including unit dose drug distribution systems and intravenous admixture programs. These systems were the responsibility for preparing distributing and administering medications by pharmacy personnel. These integrated systems shown reduced medication error rates to less than one percent. Which showed the lowest medication error rate ever documented in a hospital.8, 9

Medication errors are most common occurring in medical set up, harming at least 1.5 million people every year. Therefore, identifying the causes and attempting to prevent medication error are vital in clinical settings10 various such interventions have been devised to reduce medication errors and improve the quality of patient care and also quality of life.11 Considering geriatric population, due to their progressive functional decline in organ systems they tend to develop more chronic conditions and are often prescribed more medications.12 Due to their intricate clinical problems and undergoing multiple treatments they are more likely to get involved in medication errors.13 These may results into adverse drug reactions, increased risk of cognitive impairment, impaired balance and falls, and increased risk of morbidity, hospitalization, and mortality.12 The Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, commonly called the Beers List, is a guideline for healthcare professionals to help improve the safety of prescribing medications for older adults. The criteria are used in geriatrics clinical care to monitor and improve the quality of healthcare. The criteria are also used in clinical care, training, research, and healthcare policy to develop performance measures and document outcomes.14

A comprehensive study was done to determine the types of pharmaceutical errors, their intensity, contributing variables, and the financial impact of medication errors in various healthcare settings around the world. However, there is a scarcity of information on reporting prescription errors in the geriatric population on the Indian continent.15 The primary goal was to investigate prescribing and administration problems among geriatrics. As a result, the current study was designed to determine the rate of medication errors and offer management solutions in a multi-specialty private hospital in Gujarat's metropolitan metropolis.

Materials and Methods

A Prospective observational longitudinal study was conducted at a multi-speciality hospital, Ahmedabad, India. The study was carried out for the period of 7 months from 15th July’2014 to 15th Jan’2015.

Ethical consideration

The protocol of the study was approved by Ethics Committee, before the commencement of the study. Written informed consent of all participants were taken before inquired their data collection. Confidentiality of the participants' identity is maintained.

Protocol number

RPCP/IECHR/PG/2014-2015/R19

Data Analysis

Descriptive analyses were performed using Microsoft Excel 2007. Data were expressed as number and percentage.

Study procedure

The patients admitted in medicine ward and surgical ward were enrolled for study. The admission lists of the patients were collected from the admission department of the hospital during the time period of 9:00 am to 4:00 pm. According to the admission data of the patients, their case files were collected. Patients' age, sex, diagnosis, time of error, persons responsible for error, and consequence of errors were obtained. The admitted patients' prescriptions and treatment charts were examined for prescribing and administration errors, respectively. These two medication errors were analysed for up to two days after admission or till the discharge of patients, whichever is earlier. Principal investigator prepared a report on medication error findings and provided suggestions to quality department of the hospital. Subsequently, a medication error form was filled with detailed report of the medication errors and submitted to the quality department of the hospital for further necessary actions. Based on the report of medication error, the quality department arranged training programs as well as suggestions for improvement were given to the staff members of the hospital.

Results

During the study period, total 230 samples were collected and out of them total 105 medication errors were observed. The occurrence rate of the total medication errors was found to be 45.65%. Total 67/141 (63.81%) patients from the age group of 60 to 69 years of age were found with medication error (Figure 1 & Table 1). Additionally, higher number of prescription errors observed in each age groups (Figure 2). Over all higher number of prescription errors (98, 93.33%) were reported than administration errors (7, 6.67%).

Occurrence Rate = No. of Errors (N)*100/ Total Samples Collected

Figure 1

Flow diagram for data collection and gender distribution

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/0d8d1cfa-b0d9-44c9-ba2b-659280d526c1image1.png
Table 1

Distribution of patients with medication errors according to the age

Age g roup (Years)

No. of patients (n)

No. of m edication e rrorsn (%)

60-69

141

67 (63.81%)

70-79

77

32 (30.48%)

80-89

12

6 (5.71%)

Total

230

105(100%)

Majority of the PEs were reported in each age group of patients as depicted in Figure 2.

Figure 2

Distribution of patients with medication errors according to the age

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/0d8d1cfa-b0d9-44c9-ba2b-659280d526c1image2.png

Total 37 (35.24%) male patients showed medication errors and 68 (64.76%) female patients showed medication errors, whereas, PE was high (Figure 3).

Figure 3

Distribution of patients with medication errors according to the gender

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/0d8d1cfa-b0d9-44c9-ba2b-659280d526c1image3.png

Data of patients were collected from medical and surgical cases of the hospital and percentages of medication errors are showed in Figure 4.

Figure 4

Distribution of patients with medication errors according to the cases

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/0d8d1cfa-b0d9-44c9-ba2b-659280d526c1image4.png

Errors were identified as per the stay of hospitalization, wherein medication error was identified high on 2nd day of hospitalization as represented in Table 2

Table 2

Distribution of patients with medication errors according to the day

Types of error

Day one n (%)

Day two n (%)

Tota in (%)

Prescribing error

41(28.28%)

92(63.45%)

133(91.73%)

Administration error

5(3.45%)

7(4.83%)

12(8.28%)

Total no. of error

46(31.72%)

99(68.28%)

---

PEs was reported higher (93.33%) as a whole in the hospital including omission of dose showed high (86.67%) as shown in Table 3.

Table 3

Details of sub type of medication errors

Type of errors

Subtype of error

Percentage of errors

Prescribing errors

Omission of frequency

6.67%

Omission of dose

86.67%

Total

93.33%

Administration error

Drug administered through wrong route

0.95%

Drug administered at wrong time

5.71%

Total

6.67%

Root cause for prescribing and administration errors transpired in hospital

  • Common reasons of the prescribing errors were found during the study includes:

  1. Incomplete patient information (Allergic history, past medication history, previous diagnoses, present medication history, present concomitant illness, self-medication data).

  2. Miscommunication of drugs orders, which can involve poor handwriting, confusion between drugs with similar names, misuse of zeroes and decimal points.

  • Common reasons of the administration errors were found during the study includes:

  1. Requisition errors which lead to administration error if not recognised.

  2. Medicines were not cross-checked by nursing staff before administration.

  3. Prescribed dose was not available in pharmacy so it might be led to administration error.

  4. Lack of communication between nursing staff and medical officers.

Recommendations given according to the errors

At the end of every month, during study period, data of medication errors occurred in each month were reported to the quality department. On the basis of the medication error report, summary report was prepared and displayed at all nursing station on each floor. Points listed on displayed are as follow:

  1. Proper documentation of all administered drugs and requisition order.

  2. Each verbal order or telephonic order should be documented and signed within 24 hrs.

  3. Follow the instruction of physician and order the actual corrected dose.

  4. Cross checked the medicines after dispensing.

  5. Cross checked the medicines before administration

  6. If any errors occurred then they should fill the medication error form

  7. They should cross-check the medicine with prescription before putting the request of the drug.

  8. If the nurses have any query or doubt about the drug, then they must ask to the medical officers or other health care professionals before administration.

Discussion

Medication use is a complex process that involves coordination among various health care professionals. Medication errors may happen at any stage of patient care like prescribing, transcribing, dispensing, and administration. Studies have corroborated that medication administration errors may contribute to morbidity, mortality and increased health care expenditures.9

In this study, total 105 errors were observed from 230 samples and there was no serious medication error found. Prescribing error (93.33%) was most frequently occurred medication error. The overall frequency of medication error was 45.65% reported without causing harm to the patients in the current study. On the contrary, another study found higher reporting of errors with less severity.16 The mean of the patient was found to be 67.55± 3.15 years. Majority of (63.81 %) of errors were found in age group 60 to 69 years. Similarly, Pote et al. study reported that more than 60 years was more affected by medication errors.17 Our study demonstrated that female patients were more affected from medication errors, which is opposite to different studies performed in India, Karnataka, and Saudi Arabia.18, 19, 20

Out of 105 medication errors, 98 (93.33%) prescribing error and 7(6.67%) administration errors were reported. Similar findings were reported by different studies indicating prescription errors as major contributor in errors.17, 18, 19, 20, 21, 22 The consequences of prescribing errors may lead to ineffective treatment outcome or increase in risk of harm among patients due to drug related adverse effects or drug- drug interactions and increase pharmacy cost.

In the study, among the various types of prescribing errors, the error of omission (5.71%) and error of commission (0.95%) was most commonly perceived. Prescribing errors were predominately found in each age group of geriatric patients in our study. Similar study highlighted high incidence of omission error.23 These lead to develop consequences for misinterpretation of pharmacies, including safety threats to patients, reduced efficiency, treatment delays, and increased pharmacy cost. Medication administration errors were identified by systematic method and recorded in documentation form. They were further categorised in the types, frequency and factors responsible for medication administration errors. The data were collected from the case notes, treatment charts, medication administration records and interviewing the inpatients admitted for surgery and general medicine wards.

Higher percentage of errors 98 (93.33%) were found from the surgical ward in the study. In our study, surgical cases had higher medication error rate as compared to the medical case 7 (6.67%). It was observed that surgical patients flow was higher and which could lead higher percentage of errors compared to medical department.

Patients medication error were review on the basis of days of the hospital stay. It showed that on the 2nd day medication errors (68.45%) were higher as compared to the 1st day (31.72%). On the day of admission, the patient’s conditions will be investigated and finalized the treatment and on the second day the physician change or alter the drug and dose selection based on 1st day’s responses, hence nursing staff might failed to follow the instruction so it may lead to the medication error. Another reason was like, on day one patients received only few numbers of medications i.e. antibiotics on the 1st day of admission to surgical ward. Similarly, another study observed same finding.16 Overall, the prescription errors were higher due to incomplete prescription/ omission errors. The sub type included such as omission of dose (86.67%) and omission of frequency (6.67%). In the case of Administration error, wrong route of administration (0.95%) and wrong time of administration (5.71%) were commonly recorded. Study by Sandip Patel et al. finding was parallel to current study findings.23

We have performed reconciliation procedure to through the identifying root causes of medication errors and subsequently, training program was conducted by internal quality assurance department of the hospital based on our findings. Additionally, summary reports prepared and displayed on the nursing station on each floor and recommendations for prevention of errors were informed to healthcare personnel too.

Conclusion

The occurrence rate of the total medication errors was found to be 45.65%. Medication prescribing errors (93.33%) represent a major problem in the hospital that needs urgent intervention to optimize health outcome. The determinants of the errors were identified and training was provided.

Ethical Clearance

The protocol of the study was approved by Ethics Committee, before the commencement of the study. Written informed consent of all participants were taken before inquired their data collection. Confidentiality of the participants' identity is maintained.

Protocol Number: RPCP/IECHR/PG/2014-2015/R19

Acknowledgment

We are very much thankful to Dr. Jasmin Baldha for providing support and guidance in data collection from hospital.

Source of Funding

None.

Conflict of Interest

None.

References

1 

National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP). 2020http://www.nccmerp.org/aboutMedErrors.html

2 

ASHP Council on Professional Affairs ASHP guidelines on preventing medication errors with antineoplastic agentsAM J Hosp Pharm199359173051910.1093/ajhp/59.17.1648

3 

J V Suthar V J Patel Prescribing quality in patients with chronic diseases at primary and secondary health care facilities using prescription quality index toolInt J Basic Clin Pharmacol20143355362

4 

FDA is working with U.S. government partners, including CDC, and international partners to address the pandemic.2021http://www.fda.gov/

5 

E A Allan K N Barker Fundamentals of medication error researchAM J Hosp Pharm199047355571

6 

S Mehta N J Gogtay From the pen to the patient: Minimising medication errorsJ Postgrad Med200551134

7 

J Phillips S Beam A Brinker C Holquist P Honig L Y Lee Retrospective analysis of mortalities associated with medication errors. American journal of health-system pharmacy20015818351876https://doi.org/10.1093/ajhp/58.19.1835

8 

T A Brennan L L Leape N M Laird L Hebert A R Localio A G Lawthers Incidence of adverse events and negligence in hospitalized patients: results of the Harvard Medical Practice Study INew Engl J Med19913246370610.1056/NEJM199102073240604

9 

G Parthasarathi K N Hansen M C Nahata A text book of clinical pharmacy practice: essential concepts and skills2012486505

10 

M Ramesh M Pallepati G Parthasarathi Medication errors in clinical settings: detection and risk managementPharma Times20124411921

11 

L K Reddy A G Modi B Chaudhary V Modi M Patel Medication errors-a case studyJ Acad Hosp Administration2009211-22834

12 

D Kwan B Farrell Polypharmacy: optimizing medication use in elderly patientsPractice20132025

13 

D Fialová G Onder Medication errors in elderly people: contributing factors and future perspectivesBr J Clin Pharmacol2009676641610.1111/j.1365-2125.2009.03419.x

14 

D S Budnitz M C Lovegrove N Shehab C L Richards Emergency hospitalizations for adverse drug events in older AmericansNew Engl J Med20113652120021410.1056/NEJMsa1103053

15 

S Gaur A Sinha B Srivastava Medication errors in medicine wards in a tertiary care teaching hospital of a hill state in IndiaAsian J Pharm and Life Sci201225663

16 

S Jalpa R Rutvi Study and Evaluation of Medication Errors in a Multispecialty Private HospitalJ Hosp Pharm2015610

17 

S Pote P Tiwari Medication prescribing errors in a public teaching hospital in India: A prospective studyPharm Practice 200751172010.4321/s1886-36552007000100003

18 

L M Ross J Wallace J Y Paton Medication errors in a paediatric teaching hospital in the UK: five years operational experience. Archives of disease in childhoodArch Dis Child2000836492910.1136/adc.83.6.492

19 

N Patel M Desai S Shah P Patel A Gandhi A study of medication administration errors in a tertiary care hospitalIndian J Pharm Pract20117416817310.4103/2229-3485.192039

20 

M I Al-Jeraisy M Q Alanazi M A Abolfotouh Medication prescribing errors in a pediatric inpatient tertiary care setting in Saudi ArabiaBMC Res Notes20114116

21 

N Patel M Desai S Shah P Patel A Gandhi A study of medication errors in a tertiary care hospitalPerspect in Clin Res2016741689

22 

N D Solanki C Shah Root cause analysis of medication errors at a multi-specialty hospital in Western IndiaInt J Basic Clin Pharmacol20132681942

23 

S Patel A Patel V Patel N Solanki Study of medication error in hospitalised patients in tertiary care hospitalIndian J Pharm Pract2018111328



jats-html.xsl

© This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Article type

Original Article


Article page

220-225


Authors Details

Jalpa V. Suthar, Disha Patel


Article History

Received : 10-08-2021

Accepted : 21-08-2021

Available online : 04-09-2021


Article Metrics


View Article As

 


Downlaod Files

   








Wiki in hindi